Weight Still Top Risk Factor for Knee Arthritis
Friday, January 30, 2015 10:01 PM

Familiar risk factors for knee osteoarthritis (OA) in individuals 50 years and older -- high body mass index (BMI), previous knee injury, age, female sex, and the presence of hand OA -- were confirmed as the condition's top drivers in a new systematic review and meta-analysis with an updated evidence base.  One-fourth of cases of onset of knee pain could be attributable to being either overweight or obese.  The finding emphasizes the continued importance of weight loss as a management option for OA.

"Our calculated PAF [population attributable fraction] values demonstrate that 24.6% of cases of onset of knee pain could be attributed to being either overweight or obese,” the authors wrote.

Data from 46 published studies up to December 2012 were extracted for the systematic review to assess the association between potential risk factors and knee pain/knee OA in study cohorts with a mean age of 50 years and older. Thirty-four studies in which risk factors had consistent definitions across studies were included in the meta-analysis.

Population attributable fractions were calculated for being overweight or obese, and indicated that 5.1% of new knee pain/knee OA could be attributed to a previous injury and 24.6% could be attributed to being overweight or obese.

"The results of this review can be used clinically to help healthcare professionals identify and manage patients at risk of developing or increasing knee OA," the authors wrote. "Some, such as weight, can be targeted clinically in order to reduce the number of patients who suffer from knee OA. Patients with other risk factors such as previous knee injury, age, and female gender can be managed to reduce progression of the condition."

Source:  http://www.medpagetoday.com/Rheumatology/Arthritis/49336