Vitamin D Reduces COPD Exacerbations
Written by Editor   
Wednesday, December 10, 2014 11:42 AM

Vitamin D supplementation prevented moderate to severe exacerbations of chronic obstructive pulmonary disease (COPD) in patients with vitamin D deficiency in a multicenter, double-blind, randomized controlled trial. 

"Contrary to expectation, we did not find evidence that vitamin D3 prevented upper respiratory infections, either in the study population as a whole or in the subgroup of participants with lower baseline vitamin D status."  The supplements also did not affect the primary endpoint, which was time to first upper respiratory infection or moderate or severe exacerbation.

The authors had conducted a previous trial on patients with less severe COPD, in which they found that supplementation was helpful for patients with deficiency at baseline but had the opposite effect in those with higher levels. They write, "Taken together, findings from these two trials suggest that vitamin D supplementation should be offered to COPD patients with lower vitamin D status to reduce the risk of moderate or severe exacerbation."