High-Dose Vitamin D Modulates Immune System in MS
Written by Editor   
Wednesday, January 06, 2016 12:00 AM

Vitamin D, in high doses, seems to have a beneficial immune system effect for patients with MS.

High doses of vitamin D3 (cholecalciferol) appear to be safe and tolerable in patients with multiple sclerosis (MS), according to a single-center, randomized, double-blind pilot study.  What’s more, 10,400 IU daily of cholecalciferol increased serum 25(OH)D levels to those thought to be sufficient in MS, and had effects on immune cells not seen in MS patients taking typical daily doses of the vitamin.

The study provides Class I evidence that cholecalciferol supplementation with 10,400 IU daily is safe and well-tolerated in patients with MS and exhibits in vivo pleiotropic immunomodulatory effects, they wrote.

While results of this and other multicenter clinical trials are still needed, vitamin D "appears to be safe even at high doses and deserves further exploration," he added.

The findings provide evidence that high-dose vitamin D therapy is safe and well-tolerated in patients with MS, and may have beneficial effects on the immune system.

Source:  http://www.medpagetoday.com/Neurology/MultipleSclerosis/55470