U.K. Researchers Start Metformin Research
Written by Editor   
Tuesday, September 23, 2014 03:20 PM

Researchers in the U.K. are initiating a new trial to bolster what they call a dearth of substantial evidence for the efficacy of metformin, the staple of type 2 diabetes therapy.  The new trial will study the long-term cardiovascular effects on pre-diabetic patients.  

Said one of the medical researchers:  ""It's amazing that more than 5 decades after metformin's introduction we remain unclear about the true benefits and risks of the most widely-used anti-diabetic drug on the planet."

The current evidence for metformin, which is lacking. Following the first trial published in 1957, the next substantial study came from Garber et al. in 1997, showing good HbA1c control in a double-blind, dose-response study -- although this included only 451 patients.  

The following year, the UK Prospective Diabetes Study showed a 39% reduced risk of heart attack with metformin and a 36% reduced risk of overall mortality -- and follow-up data reported in 2008 showed similar reductions (33% and 27%, respectively). Again, this analysis includes only 753 patients.

Source:  http://www.medpagetoday.com/MeetingCoverage/EASD/47740