Inflammation, Not Acid, Cause of GERD, Study Suggests
Written by Editor   
Wednesday, June 08, 2016 12:00 AM

Gastroesophageal reflux disease (GERD) may be caused by an immune reaction, rather than direct chemical injury from stomach acids, according to results from a small, single-center study.  These findings may suggest that the pathogenesis of reflux esophagitis may be cytokine-mediated rather than the result of chemical injury.

Since 1935, convention has held that GERD, which affects about 20% of Americans, results from irritation of the esophageal lining as a result of refluxed acid from the stomach. A recent study in rats, however, has suggested that GERD may not be a result of chemical injury but, rather, a result of an immune reaction. Shifting the focus away from the "burning" effect of stomach acid toward an immune reaction may help explain subtypes of GERD that have been recently recognized.

The findings may also have implications for therapy, new therapies that target the inflammatory cascade may help treat patients with more severe or refractory GERD.


Source:  http://www.medscape.com/viewarticle/863413