Subclinical Inflammation Often Present in Psoriasis
Written by Editor   
Saturday, April 30, 2016 12:00 AM

Patients with psoriasis but not psoriatic arthritis (PsA) have a high prevalence of subclinical inflammatory lesions, and these changes are associated with later development of PsA, German investigators have found.

In their longitudinal analysis, nearly half of the psoriasis patients showed MRI evidence of subclinical inflammation, compared with only 13% of healthy controls. Sixty percent of the patients had arthralgia. The implication is that "subclinical inflammation appears to substantially influence the risk of patients with psoriasis to progress to PsA. This transition to PsA is considered being a critical step in defining the onset of musculoskeletal disease in patients with psoriasis and to shape early interventions.  In our longitudinal analysis we show that both symptoms related to arthralgia as well as subclinical synovitis influence the risk for progression to PsA."

Overall, about 15% to 30% of patients with psoriasis develop PsA. Patients with psoriasis with MRI synovitis and symptoms related to arthralgia had a 55.5% likelihood of developing PSA within 1 year, compared with 15.3% of patients with psoriasis without signs of synovitis or arthralgia.