Insulin Dysregulation May Impair Glucose Metabolism in Brain
Written by Editor   
Thursday, August 06, 2015 12:00 AM

An imaging study of participants at risk for Alzheimer's disease (AD) has found that insulin resistance was associated with lower regional cerebral glucose metabolism, and that "this information will be central to developing prevention and treatment therapies centered on insulin dysregulation."

Researchers found that higher homeostatic model assessment of peripheral insulin resistance (HOMA-IR) was associated with lower glucose metabolism across much of the frontal, lateral, parietal, lateral temporal, and medial temporal lobes.

In addition, lower glucose metabolism in the left medial temporal lobe was associated with worse performance on immediate memory and delayed memory factor scores.  Previous research has tied insulin resistance to a higher risk of Alzheimer’s, and an autopsy study showed that insulin resistance, along with type 2 diabetes, may contribute to the development of neuritic plaques, which may contribute to the development of Alzheimer's disease.

The authors noted that there are several mechanisms that could underlie the associations that they found. Amyloid deposition and loss of neuronal function because of mitochondrial damage might explain it. A disease common to both insulin resistance and Alzheimer's disease is type 2 diabetes, they added.

"Additional studies are needed to clarify interactions between insulin resistance, parental history, and APOE ε4 across the spectrum of disease development, from preclinical AD to diagnosed dementia," wrote the authors. "This information will be central to developing prevention and treatment therapies centered on insulin dysregulation."


Source:  http://www.medpagetoday.com/Neurology/AlzheimersDisease/52792